Author

Serafima Guseva

Centre National de la Recherche ScientifiqueORCID 0000-0001-9706-5035Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Organism:virus· 1

Frequent Co-Authors

Hashim M. Al‐HashimiiD· 2 shared Or SzekelyiD· 2 shared Ainan GengiD· 1 shared Akanksha ManghraniiD· 1 shared Aldo R. Camacho‐ZarcoiD· 1 shared Atul Kaushik RangaduraiiD· 1 shared Bei LiuiD· 1 shared Damien Maurin· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

Hashim M. Al‐HashimiORCID

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3 papers

Recent·Most cited

BiochemistryAngewandte Chemie International EditionPeer-reviewedApr 11, 2025

An A-T Hoogsteen base pair in a naked DNA hairpin motif: A Protein-Recognized Conformation

Serafima Guseva, Or Szekely, Ainan Geng…·Hashim M. Al‐Hashimi

The paper shows that an A-T Hoogsteen base pair forms in naked DNA hairpins without protein binding, and identifies a DNA-specific motif stabilized by this pairing.

1 citation

DNA methylationexperimental assay

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BiochemistryBiochemistryPeer-reviewedFeb 21, 2025

Quantitative and systematic NMR measurements of sequence-dependent A-T Hoogsteen dynamics uncovers unique conformational specificity in the DNA double helix

Akanksha Manghrani, Atul Kaushik Rangadurai, Or Szekely…·Hashim M. Al‐Hashimi

This study measures sequence-dependent A-T Hoogsteen dynamics in DNA using NMR, revealing distinct conformational specificity and sequence dependence.

6 citations

experimental assay

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BiochemistryScience AdvancesPeer-reviewedAug 2, 2024

A specific phosphorylation-dependent conformational switch of SARS-CoV-2 nucleoprotein inhibits RNA binding

Maiia Botova, Aldo R. Camacho‐Zarco, Jacqueline Tognetti…·Martin J Blackledge

This study identifies a phosphorylation-dependent conformational switch in SARS-CoV-2 nucleoprotein that inhibits RNA binding by altering domain interactions.

42 citationstop 1%

virusprotein structure

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