Hashim M. Al‐Hashimi

The paper shows that an A-T Hoogsteen base pair forms in naked DNA hairpins without protein binding, and identifies a DNA-specific motif stabilized by this pairing.

This study measures sequence-dependent A-T Hoogsteen dynamics in DNA using NMR, revealing distinct conformational specificity and sequence dependence.

This study uses high-throughput thermodynamic measurements to explore how sequence changes affect the binding properties of RNA tetraloop receptor motifs, revealing complex sequence-fitness landscapes.

This paper measures 8OG syn-anti flips and Hoogsteen breathing dynamics in damaged DNA using 1H CEST NMR, revealing their impact on DNA conformation and repair.

This study uses NMR to show that G*T/U mismatches in RNA:DNA hybrids can form Watson-Crick-like conformations, potentially contributing to transcription errors and CRISPR/Cas9 off-target effects.

The paper shows that mRNAs interact with disordered regions of proteins like MYC to control their activity by enabling specific protein complexes formed in translation sites called TIS granules.