Päivi Pihlajamaa

The paper shows classical enhancers influence 3D genome structure by linking DNA sequence to transcriptional condensates and chromatin organization through specific transcription factors.

The paper investigates how inhibiting chromatin modifier enzymes in cancer cells leads to cell-type-specific derepression of transposable elements, enhancing immune response through distinct mechanisms.

The paper identifies sequence determinants of human gene regulatory elements by analyzing transcriptional activity of long DNA sequences in three cell types, revealing distinct enhancer types and TF subtypes based on motif content and activity patterns.

This study uses a novel competitive genome editing assay to identify MYC oncogene transcriptional targets by analyzing the effects of E-box mutations on cellular fitness.

This study shows that combining oncogenes with lineage reprogramming can transform human cells into tumorigenic liver-like cells.