Ville Tiusanen

This study shows that mitochondrial DNA replication defects in skeletal muscle alter methylation patterns of phospholipids, histones, and RNA, linking mitochondrial dysfunction to methylation remodeling in mitochondrial myopathy.

The paper shows classical enhancers influence 3D genome structure by linking DNA sequence to transcriptional condensates and chromatin organization through specific transcription factors.

The paper investigates how inhibiting chromatin modifier enzymes in cancer cells leads to cell-type-specific derepression of transposable elements, enhancing immune response through distinct mechanisms.

This study shows KSHV uses SOX18 to maintain viral episomes in LECs by enhancing chromatin accessibility.