Nina G. Friedman

This paper develops and validates new tools for multi-organ neuroimaging of neural and vascular dynamics in the brain and spinal cord, including 3D-printed implants and bioluminescent imaging.

The paper measures neural activation functions in awake mice using optogenetics, finding neurons exhibit a supralinear-to-linear response that allows filtering of inputs during suppression.

The paper introduces a new bioluminescent optogenetic molecule (LMO7) that enhances chemogenetic activation efficacy compared to existing variants, showing improved neuronal activity modulation and behavioral control.

The paper introduces a bicistronic AAV vector that co-expresses GCaMP8s and stChrimsonR in mice, enabling stable and robust two-photon holographic stimulation and imaging of cortical neurons.

The paper introduces a method to control synaptically connected neurons using bioluminescent light, validated in cultured neurons and mice.

The paper tests the relationship between bioluminescent photon emission and optogenetic effects in neocortex using BL-OG molecules and Coelenterazine doses.