Kristi L. Helke

This study demonstrates that MUC4-targeted CAR-T cells effectively eliminate chemotherapy-resistant CRC cells in vitro and reduce tumor burden in vivo, showing promise for treating chemoresistant colorectal cancer.

This paper shows that combining MYC and p53-R270H mutations in a mouse model generates high-grade serous ovarian and uterine serous carcinomas with human-like genetic and transcriptomic features.