Manish Sagar

This study shows that sialic acid-binding bacterial lectins enhance HIV-1 infectivity in vitro and mucosal transmission in humanized mice by promoting virus-cell attachment and spread.

This study shows defective HIV proviruses trigger type I interferon responses in myeloid cells through MDA5-dependent pathways, contributing to chronic inflammation in people with HIV.

This study identifies Bloom syndrome helicase (BLM) as a host factor that promotes HIV-1 reverse transcription and integration in macrophages through CRISPR screening and functional assays.

NanoHIVSeq is a UMI-free pipeline for processing HIV Env sequences from ONT data, achieving high accuracy and efficiency in variant recovery.

This study identifies the MDA5-IRF5 axis as critical for HIV-1 icRNA-induced inflammatory responses in macrophages, with IRF5 mediating enhanced IP-10 expression in older individuals.

The paper finds that recent endemic coronavirus infection is associated with higher SARS-CoV-2 cross-reactive Fc receptor binding antibodies, which may contribute to reduced severe COVID-19.

The paper finds that prior SARS-CoV-2 infection, but not vaccination, reduces subsequent symptomatic endemic coronavirus incidence and is associated with stronger CD8+ T cell responses to non-structural proteins.