Yoseph Addadi

Spatial transcriptomics of live healthy donor livers shows most hepatocyte genes are zonated, with key functions pericentrally shifted versus mouse, pig, boar and cow.

The paper uses spatial transcriptomics to analyze thyroid heterogeneity, identifying a damage-response thyrocyte state that balances with hormone-producing states across scales.

This study uses spatial transcriptomics and proteomics to analyze IDH-mutant gliomas, revealing distinct spatial organization patterns across tumor grades.

This study uses spatial and single-cell transcriptomics to show that celiac disease alters enterocyte states by promoting aberrant zonal co-expression and metaplastic cells.

This study shows that Piezo2 in sensory neurons regulates brown and beige fat metabolism, preventing systemic hypermetabolism and improving insulin sensitivity.

This study uses spatial transcriptomics and proteomics to reveal three modes of cellular organization in glioblastoma, with hypoxia driving a 5-layered global architecture.

This paper introduces CombPlex, a combinatorial staining method combined with deep learning to measure more proteins at single-cell resolution without needing specialized imaging equipment.

This paper develops a transgene-free human post-implantation embryo model from genetically unmodified naive PSCs, recapitulating key developmental stages and extra-embryonic tissues.

The paper introduces DestVI, a method for multi-resolution spatial transcriptomics analysis that captures continuous cell state variation, and applies it to study inflammation in lymph nodes and tumors.

This study uses APEX proximity-proteomics to analyze the spatio-temporal proteomic changes during stress granule disassembly, identifying novel proteins and revealing SUMOylation's role in ALS pathogenesis.

The paper introduces 3D MAPs, a pipeline for analyzing chondrocyte morphology in growth plates, revealing allometric growth strategies and GDF5's regulatory role in tibia development.

This study identifies BACH family members as regulators of VEGFC expression, impacting angiogenesis and lymphangiogenesis in zebrafish and mouse models.

The paper identifies global and regional genetic regulators that control the modular patterning of bone superstructures during long bone development.

The paper analyzes 3D nuclear morphology in mouse growth plates to reveal differences in nuclear shape across differentiation stages and opposing growth plates.