Ofra Golani

The paper identifies persistent stromal reprogramming in mucosal healing of ulcerative colitis and links it to therapeutic response prediction.

This study uses spatial transcriptomics to map subcellular mRNA localization across tissues, revealing conserved and tissue-specific patterns.

Spatial transcriptomics of live healthy donor livers shows most hepatocyte genes are zonated, with key functions pericentrally shifted versus mouse, pig, boar and cow.

The paper uses spatial transcriptomics to analyze thyroid heterogeneity, identifying a damage-response thyrocyte state that balances with hormone-producing states across scales.

This study uses spatial transcriptomics and proteomics to analyze IDH-mutant gliomas, revealing distinct spatial organization patterns across tumor grades.

This study uses spatial and single-cell transcriptomics to show that celiac disease alters enterocyte states by promoting aberrant zonal co-expression and metaplastic cells.

This paper introduces PINCHs, bifunctional molecules that sequester homomeric proteins by inducing polymerization, demonstrating efficacy in knocking down protein function in cells.

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.

The paper shows cancer-associated fibroblasts suppress NK cell cytotoxicity by acting as decoys, leading to poor disease outcomes in breast cancer.

The paper models a macrophage-myofibroblast circuit to predict fibrosis types and shows targeting the myofibroblast autocrine loop reduces fibrosis after myocardial infarction.

The paper identifies Mif as a regulator of tumor immune evasion in low intra-tumor heterogeneity melanoma by analyzing single-cell RNA sequencing data and validating in patient data.

The paper shows that egg-derived MVBs use the LAP pathway to eliminate paternal mitochondria in Drosophila, with potential parallels in mammals.

The paper introduces DestVI, a method for multi-resolution spatial transcriptomics analysis that captures continuous cell state variation, and applies it to study inflammation in lymph nodes and tumors.

BIAFLOWS provides a framework to document, deploy, and benchmark bioimage analysis workflows, enabling reproducible and fair comparisons of image analysis methods.

This study identifies BACH family members as regulators of VEGFC expression, impacting angiogenesis and lymphangiogenesis in zebrafish and mouse models.

This study shows that hyaluronan regulates vascular remodeling and NK cell function during early pregnancy, affecting implantation success.