Andrew G. Fraser

The paper uses deep mutational scanning to analyze structure-switching aptamers, identifying base requirements, base-pairing, and regions critical for sensitivity or specificity.

This paper introduces a novel metabolomics platform using barcoded structure-switching aptamers for high-sensitivity, multiplexed detection of metabolites and drugs.

The paper identifies natural variation in wah-1 expression affecting RQDM in C. elegans and shows similar complexity in parasitic nematodes.

The paper identifies a novel family of benzimidazole compounds that selectively inhibit Complex I in helminths, potentially serving as new anthelmintics.

The paper identifies 4 helminth-specific enzyme targets for RQ-dependent metabolism that could be inhibited to develop new anthelmintics.

The paper shows helminths switch from ubiquinone to rhodoquinone synthesis via alternative splicing of coq-2 in anaerobic environments.

This study identifies the pathway for Rhodoquinone biosynthesis in C. elegans and develops an assay to screen for drugs blocking RQ-dependent metabolism.

The paper examines acute drug effects on C. elegans movement, revealing complex recovery phases and drug-specific responses that highlight biological network plasticity.