Dimitri Y. Chirgadze

This paper presents a cell-free method to rapidly produce and determine cryo-EM structures of GPCR-nanodisc complexes, achieving structural-grade results in four days.

This study determines the structure of TbAQP2 bound to drugs and glycerol, revealing how mutations in the channel lead to drug resistance in Trypanosoma brucei.

This study identifies how DNA polymerase Lambda interacts with the NHEJ complex via Ku70/80, revealing the molecular basis for its recruitment and activity in DNA repair.

This paper identifies NACHO as an ER-resident protein that facilitates the assembly of pentameric ligand-gated ion channels by interacting with subunit interfaces.

This study reports cryo-EM structures of human mitochondrial tRNA maturation complexes, revealing the molecular mechanisms of tRNA processing steps and their sequential order.

The paper reports the cryoEM structures of the RapZ:GlmZ complex and its interaction with RNase E, revealing mechanisms of RNA regulation in bacterial cell envelope biogenesis.