Ben F. Luisi

This study shows IsdH binds HbHp but does not support S. aureus growth under iron restriction when HbHp is the sole iron source, suggesting HbHp recognition has roles beyond iron acquisition.

The paper shows YicC, an RNA enzyme, preferentially cleaves specific sRNAs when they are in active, target-engaged structures, revealing a mechanism for substrate-induced conformational changes.

The paper identifies YbjP as a lipoprotein partner for E. coli TolC, showing its interaction with TolC's periplasmic surface and N-terminal lipid moiety, and presents cryo-EM structures of related efflux pump complexes.

This study determines the cryo-EM structure of the MmpS5L5 efflux pump in Mycobacterium tuberculosis and identifies mutations that enhance bedaquiline efflux, suggesting new resistance mechanisms.

The paper identifies a compound that disrupts the TolC-AcrA interface of the E. coli efflux pump, leading to pump disassembly and reduced antibiotic resistance.

The paper identifies two conserved residues in Hfq critical for stabilizing small regulatory RNAs under nitrogen starvation.

This study shows that dinoflagellates can acquire and utilize haptophyte-derived plastids, demonstrating that complex plastids can be transferred between hosts.

This study reports cryo-EM structures of human mitochondrial tRNA maturation complexes, revealing the molecular mechanisms of tRNA processing steps and their sequential order.

The paper reports the cryoEM structures of the RapZ:GlmZ complex and its interaction with RNase E, revealing mechanisms of RNA regulation in bacterial cell envelope biogenesis.

The paper describes how Hfq and Crc form mRNA-specific ribonucleoprotein assemblies that enable selective translational repression in Pseudomonas aeruginosa.

The paper identifies the stem loop 2 motif as a vulnerable site in SARS-CoV-2 that can be targeted by antisense oligonucleotides to inhibit replication and infection.