Author

Alexander V. Statsyuk

University of HoustonORCID 0000-0001-9954-8049Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Patrick Chuong· 2 shared Sandipan Roy Chowdhury· 1 shared Victoria E. Mgbemena· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersCell Biology

Patrick Chuong

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintDec 30, 2023

Development of a PROTAC Targeting Chk1

Sandipan Roy Chowdhury, Patrick Chuong, Victoria E. Mgbemena, Alexander V. Statsyuk

This paper designs and synthesizes Chk1 degraders using a promiscuous kinase binder and thalidomide, showing concentration-dependent reduction of Chk1 in A375 cells.

DOI 10.1101/2023.12.30.573733

humanexperimental assay

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BiochemistrybioRxivPreprintOct 14, 2023

Selective Smurf1 E3 ligase inhibitors that prevent transthiolation

Patrick Chuong, Alexander V. Statsyuk

This paper identifies and characterizes selective Smurf1 inhibitors that block the trans-thiolation reaction, showing high selectivity over Smurf2.

1 citation

humanmouse

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