Timothy C. Yu

The paper identifies molecular interactions between influenza HAs and MHC-II, showing avian MHC-II enables more efficient entry than human MHC-II for most H5 HAs and reveals structural and functional similarities across different HA subtypes.

The paper compares sequence constraints across influenza HA subtypes and finds that despite similar structures, ~50% of sites show diverged amino-acid preferences.

This study shows RSV F evolution can escape some monoclonal antibodies but does not strongly reduce neutralization by human polyclonal sera, and introduces a tool to measure neutralization against RSV strains.

The paper measures how mutations in influenza HA affect function, stability, and antibody neutralization, showing epistasis enables antigenic change but cannot overcome pleiotropic costs that restrict evolutionary trajectories.

The paper maps how HA mutations affect neutralization by serum from different age groups, showing age-dependent antigenic effects and implications for viral evolution.

ACE integrates clustering and marker gene selection into a single deep learning workflow to identify discriminative and nonredundant gene panels.

The paper profiles 8,269 IPTG-inducible promoters to model gene expression and identify optimal promoter architectures for predictable transcriptional control.