Bernadeta Dadonaite

This study evaluates an H5 mRNA-LNP vaccine in lactating dairy cows, finding it reduces viral replication and disease in mammary glands.

This study shows bovine H5N1 influenza viruses have adapted to efficiently use NeuGc receptors in cattle, enhancing replication without significantly altering zoonotic risk.

The paper investigates how IGHV3-53/3-66 antibodies from Omicron BA.1 infection neutralize emerging SARS-CoV-2 variants through structural and mutational analysis.

The paper identifies molecular interactions between influenza HAs and MHC-II, showing avian MHC-II enables more efficient entry than human MHC-II for most H5 HAs and reveals structural and functional similarities across different HA subtypes.

The paper examines how mutations in the HCoV-229E spike affect receptor binding and serum neutralization, revealing counterbalancing effects on these functions.

The paper compares sequence constraints across influenza HA subtypes and finds that despite similar structures, ~50% of sites show diverged amino-acid preferences.

This paper identifies spike mutations in recent SARS-CoV-2 variants that reduce neutralization by human antibodies and clinically relevant monoclonal antibodies, highlighting key sites and mechanisms affecting antigenicity and function.

Booster SARS-CoV-2 mRNA vaccine recruits and broadens GC B cell responses targeting a highly conserved site on receptor binding domain of spike glycoprotein.

Stabilizing H5 HA mutations enhance neutralizing antibody responses by shifting epitope targeting toward the receptor binding site in vaccinated mice.

The paper measures how mutations in influenza HA affect function, stability, and antibody neutralization, showing epistasis enables antigenic change but cannot overcome pleiotropic costs that restrict evolutionary trajectories.

This study compares neutralizing antibody specificities between recently infected infants and immune-imprinted adults, finding distinct targeting of SARS-CoV-2 spike domains.

The paper designs bispecific antibodies that retain neutralization activity against multiple SARS-CoV-2 variants, including Omicron subvariants.

This study uses deep mutational scanning to analyze H5 hemagglutinin mutations and their impact on pandemic risk factors in influenza viruses.

This study compares IgG antibody responses from SARS-CoV-2 infection, vaccination, and hybrid immunity, finding that hybrid immunity retains the imprint of the initial exposure and enhances antibody breadth and affinity.

This study uses deep mutational scanning to assess how mutations in SARS-CoV-2 spike proteins affect ACE2 binding, cell entry, and serum escape, linking these effects to clade growth rates.

The paper develops a method to identify mutations with shifted effects across DMS experiments on SARS-CoV-2 spike homologs, finding some mutations show >1,000-fold differences in impact across variants.