MicrobiologyNature CommunicationsPeer-reviewed
Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies
Durgadevi Parthasarathy, Karunakar Reddy Pothula, Kim-Marie A. Dam…·Alon Herschhorn
This paper shows that some HIV-1 transmitted/founder Envs are incompletely closed, making them sensitive to antibodies targeting open conformations, and highlights the importance of Env conformational flexibility for bnAb neutralization.
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