Karunakar Reddy Pothula

This paper shows that some HIV-1 transmitted/founder Envs are incompletely closed, making them sensitive to antibodies targeting open conformations, and highlights the importance of Env conformational flexibility for bnAb neutralization.

The paper determines cryo-EM structures of Langya virus fusion protein in pre- and post-fusion states, revealing structural differences and a potential mechanism for fusion initiation.