Yoshikazu Hattori

HA10, a humanized anti-ADAMTS13 antibody, preserves residual ADAMTS13 activity to prevent cardiovascular bleeding without causing thrombosis in non-human primate models.

This study shows Ca2+ induces PDIA6 phase separation, enhancing proinsulin folding and preventing aggregation through recruitment of PDIA3.

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

This study investigates how the K76E mutation in PPIA affects protein dynamics and function, finding that it impairs isomerase activity through allosteric network disruption rather than structural changes.