Masaki Okumura

HA10, a humanized anti-ADAMTS13 antibody, preserves residual ADAMTS13 activity to prevent cardiovascular bleeding without causing thrombosis in non-human primate models.

This study develops a chemical method to enhance oxidative protein folding within PDIA6 condensates, showing up to 12-fold acceleration in vitro and improved insulin secretion in cells.

This study uses Raman-Brillouin microscopy to show lipids are enriched in heterochromatin and influence its mechanical properties in living cells.

This study examines how different amyloid-beta fibrils affect sleep and cortical activity in mice, revealing distinct impacts of Aβ40 and Aβ42.

This study shows Ca2+ induces PDIA6 phase separation, enhancing proinsulin folding and preventing aggregation through recruitment of PDIA3.

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

This study identifies Kapβ2 as a target of DPRs, showing how DPR binding alters its phase-modifying function, leading to toxic RBP condensates in ALS models.

The paper compares how PDI and ERp46 recognize client proteins during oxidative folding, showing distinct mechanisms that influence disulfide bond formation and protein quality control.

The paper reports the atomic structure of glucagon amyloid fibrils using cryo-EM, revealing a dimeric architecture and distinct from previous models.