Nicolas Locker

The paper introduces a capillary-based subcellular sampling method combined with LC-MS to analyze stress granule proteomes in single cells, identifying 405 high-confidence proteins with minimal cytosolic contamination.

This study investigates YFV-induced stress granules, revealing their enrichment in mitochondrial proteins and their role in mitochondrial dysfunction during infection.

This study shows that stress granule formation during FMDV infection is independent of innate immune activation, and that preventing their disassembly reduces viral replication.

This study shows that CLN3 deficiency disrupts stress granule dynamics and translation, linking it to neurodegenerative disease mechanisms.

This study shows that norovirus infection leads to the formation of virus-specific granules and disrupts eIF2α signaling to evade host stress responses.