Charis Eng

NeuroPupil improves cross-species pupillometry with a deep learning framework, achieving better accuracy and efficiency while enabling reliable biological insights.

This study investigates how the breast tumor microbiome interacts with CD8+ TILs and metabolites, showing that Staphylococcus influences anti-tumor immunity and T cell-associated metabolites.

This study examines sensory behaviors and transcriptomic changes in a Pten heterozygous mouse model of ASD, identifying altered somatosensory neuron development and subtype-specific marker expression.

The paper compares neurobehavioral profiles of Smith-Kingsmore Syndrome and PTEN Hamartoma Tumor Syndrome, identifying distinct features and diagnostic markers.

The paper uses molecular dynamics simulations to analyze four SCN2A variants, revealing how they affect channel structure and function, with R937C being the most unstable.

The paper introduces PIONEER, a deep learning framework for predicting protein-protein interfaces, and shows disease mutations are enriched in these interfaces, identifying oncoPPIs linked to cancer survival and drug responses.

The paper identifies two new transcription start regions (TSRs) upstream of the PTEN promoter, expanding its regulatory landscape and suggesting potential clinical implications for PTEN-related disorders.

This study uses explicit solvent simulations to reveal how PTEN interacts with phosphoinositide-enriched membranes, elucidating its mechanism of activation and membrane anchoring.

The paper examines sex differences in COVID-19 outcomes and immune responses using single-cell RNA-sequencing and clinical data, finding higher risk for males and potential mechanisms for sex-specific treatments.

This study identifies disease mutations that perturb protein-protein interactions in the human 3D interactome, showing their association with cancer survival and drug response.

This study combines deep mutational scanning data with clinical data to link PTEN variants to specific clinical outcomes and risk levels.