Kazuki Nagata

This study shows that butyrate, a short-chain fatty acid, modulates dendritic cell development and surface molecule expression through epigenetic mechanisms and transcription factors.

This study investigates the role of the IRE1α-XBP1 axis in IgE-dependent mast cell activation and finds it is critical for degranulation and cytokine release in allergic responses.

This study identifies GATA2 as a key regulator of sST2 expression in mast cells through chromosomal conformational changes.

The paper investigates the transcriptional regulation of CD103 in mast cells and dendritic cells, showing that PU.1 transactivates CD103 expression while GATA2 represses it.

The paper investigates the transcriptional regulation of basophil-specific protease genes Mcpt8 and Mcpt11, identifying C/EBPα, GATA2, TGF-β signaling, and epigenetic factors as key regulators.

This study identifies kaempferol as a flavonoid that enhances Treg development via AhR-mediated and PU.1/IRF4-dependent activation of Aldh1a2/RALDH2 in dendritic cells, reducing inflammation in a food allergy model.

This study shows NR4A3 deficiency reduces contact hypersensitivity but worsens psoriasis by altering dendritic cell gene expression.