Author

Charles A. Wartchow

ORCID 0000-0002-0123-1455Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

Antonin V. TutteriD· 2 shared Dennis L. BuckleyiD· 2 shared Fupeng MaiD· 2 shared Jonathan M. SolomoniD· 2 shared Lei XuiD· 2 shared Pasupuleti Rao· 2 shared Aleem FazaliD· 1 shared Alexander N.R. WeberiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Antonin V. TutterORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintJun 15, 2026

Scalable platform for cellular and biochemical screening of combinatorial small-molecule libraries in droplets

Mihajlo Todorovic, Laura West, Frederic D. Sigoillot…·Ken Yamada

The paper introduces a scalable platform for screening combinatorial small-molecule libraries in droplets, demonstrating its effectiveness in discovering chemical inducers of proximity and supporting machine learning-based drug design.

1 citation

proteomicsexperimental assay

𝕏 PostBluesky

ImmunologyCell chemical biologyPeer-reviewedJul 1, 2025

A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation

Aude Sylvain, Natacha Stoehr, Fupeng Ma…·Zuni I. Bassi

This paper identifies NK7-902, a CRBN molecular glue degrader of NEK7, showing partial inhibition of NLRP3 inflammasome activation in humans and full activity in mice, but only transient effects in non-human primates.

27 citationstop 2%

humanmouse

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BiochemistryNature Chemical BiologyPeer-reviewedJun 24, 2025

A small molecule VHL molecular glue degrader for cysteine dioxygenase 1

Antonin V. Tutter, Dennis L. Buckley, Andrei A. Golosov…·Gregory A. Michaud

The paper identifies a small molecule that acts as a molecular glue degrader for CDO1 by recruiting it into the VHL E3 ligase complex, leading to its degradation.

41 citationstop 1%

experimental assaydrug response / drug discovery

𝕏 PostBluesky