Amy C. Gross

This study identifies the structural domains of the VGLL2::NCOA2 fusion-oncogene essential for tumorigenesis and suggests therapeutic targeting of these domains.

SCANBIT identifies tumor cell populations in scRNA-seq data by using pseudobulked SNV calls, showing that mutational burden affects identification accuracy.

This study shows NR0B1 alters the 9-cis-retinoic acid response in Ewing Sarcoma cells by modulating nuclear receptor activity, suggesting NR0B1 inhibition could enhance retinoid therapy.

This study identifies metastasis-initiating osteosarcoma subpopulations that interact with lung and tumor cells to form a metastatic niche, highlighting tumor-stromal interactions as key drivers of metastasis.

This study identifies fibrosis as a targetable vulnerability in osteosarcoma lung metastasis by showing nintedanib inhibits metastatic progression through anti-fibrotic effects.

This study shows trabectedin enhances oncolytic virotherapy by reducing anti-viral barriers and boosting immune-mediated tumor regression in preclinical models.