Author

Canchai Yang

Michigan State UniversityORCID 0000-0002-0125-9298Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:wet-lab / biochemical assay· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Dohun PyeoniD· 3 shared Lexi VuiD· 3 shared M. I. KhaliliD· 3 shared Craig C. WelboniD· 2 shared Harrison Nabors· 2 shared Smriti Chadha· 2 shared William Charles SpanosiD· 2 shared Abigail Z. BennettiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

Dohun PyeonORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMar 18, 2026

ULK1 drives NDP52-mediated selective autophagic degradation of MHC-I to promote immune evasion in HPV-positive head and neck cancer

Lexi Vu, Nicholas S. Giacobbi, M. I. Khalil…·Dohun Pyeon

This study identifies ULK1-driven autophagy as a mechanism by which HPV+ HNC cells degrade MHC-I, promoting immune evasion and tumor growth.

DOI 10.64898/2026.03.14.711071

humanproteomics

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Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewedMar 9, 2026

The membrane-associated ubiquitin ligase MARCHF8 promotes cancer immune evasion by degrading MHC class I proteins

M. I. Khalil, Jie Wang, Lexi Vu…·Dohun Pyeon

This study identifies MARCHF8 as a driver of cancer immune evasion by degrading MHC-I proteins and shows its inhibition enhances antitumor immunity and response to immunotherapy.

4 citationstop 3%

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MicrobiologyJournal of VirologyPeer-reviewedJan 16, 2024

The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer

M. I. Khalil, Canchai Yang, Lexi Vu…·Dohun Pyeon

This paper shows that MARCHF8 stabilizes HPV E7 by degrading CUL1 and UBE2L3, preventing E7 degradation in HPV+ HNC cells.

14 citations

humanproteomics

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