Jie Wang

Omics-scale decoding of protein N-glycosylation using protein language model embeddings

The paper decodes protein N-glycosylation sites from protein language model embeddings using a zero-shot framework, revealing biological insights and disease associations.

From pose to behavior: SABER integrates identity-resolved multi-animal pose tracking with large-language-model-based behavioral factor discovery

SABER improves pose tracking and behavioral analysis in multi-animal videos by integrating identity-preserving tracking with behavioral factor discovery, showing reduced approach behavior in depression-susceptible mice.

Sequential Proofreading Enhances Specificity and Potency of CRISPR-CasX-based Epigenetic Repressors

This paper introduces ELXRs, CRISPR-CasX-based epigenetic repressors that use sequential proofreading to enhance specificity and potency by reading chromatin state before DNA methylation.

Unique CD8+ T Cell Populations Expand during ART and Predict Delayed HIV-1 Rebound

The paper identifies a unique CD8+ T cell population that expands during ART and predicts delayed HIV-1 rebound.

Scalable longitudinal imaging and transcriptomics of cells in dynamic enclosures

This paper develops a platform for longitudinal imaging and transcriptomics of live cells, revealing adaptive drug-resistant states and key drivers of cellular function through integrated analysis.

Funneliformis mosseae and Pseudomonas putida-symbiotic interaction promote drought resilience in Citrus reticulata

This study shows that combining Funneliformis mosseae and Pseudomonas putida improves drought resilience in Citrus reticulata by enhancing physiological traits and gene expression.

The membrane-associated ubiquitin ligase MARCHF8 promotes cancer immune evasion by degrading MHC class I proteins

This study identifies MARCHF8 as a driver of cancer immune evasion by degrading MHC-I proteins and shows its inhibition enhances antitumor immunity and response to immunotherapy.

Organoid Profiler: Automated, high-throughput and quantitative morphological characterization uncovers conserved longitudinal developmental kinetics in microfluidics-engineered organoids

The paper introduces Organoid Profiler, a deep-phenotyping pipeline that quantitatively characterizes microfluidics-engineered organoids, revealing conserved developmental kinetics and improved viability and homogeneity.

HSV-1 orchestrates host RAP80 ubiquitination by ICP0 and UL36USP to promote viral survival

This study identifies RAP80 as a target of HSV-1 ubiquitination enzymes ICP0 and UL36USP, showing how HSV-1 modulates host proteins at different infection stages to promote its survival.

IL-17A-driven Macrophage Disorder Promotes Plaque Instability in Psoriatic Atherosclerosis

This study shows IL-17A promotes plaque instability in psoriatic atherosclerosis by enhancing macrophage inflammation and disrupting lipid metabolism.

Stathmin 1 regulates mitophagy and cellular function in hematopoietic stem cells

This study shows that Stathmin 1 regulates mitophagy and mitochondrial health in hematopoietic stem cells by maintaining microtubule architecture and autophagy processes.

Large Serine Integrase Off-Target Discovery with Deep Learning for Genome Wide Prediction

The paper introduces IntQuery, a deep learning model that predicts LSI off-target activity genome-wide using data from Cryptic-seq.

Drosophila larval light avoidance is negatively regulated by temperature through two pairs of central brain neurons

This study identifies two pairs of Drosophila central brain neurons that negatively regulate light avoidance behavior by temperature through modulating downstream neural activity.

A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety

The paper identifies a novel GABAergic projection from the BNST to accumbal parvalbumin neurons that modulates anxiety-related behavior through inhibitory synaptic transmission.

A comparative assessment of aging-related NADPH diaphorase positivity in the spinal cord and medullary oblongata between pigeon and murine

This study compares aging-related NADPH diaphorase positivity in the spinal cord and medullary oblongata of pigeons with rats and mice, identifying age-related changes and potential markers of aging.

Factorbook Motif Pipeline: A de novo motif discovery and filtering web server for ChIP-seq peaks

The paper introduces a web server for de novo motif discovery and filtering in ChIP-seq data, enhancing the reliability of motif analysis through statistical testing.