Quen J. Cheng

This study shows that IFNγ-induced memory in macrophages relies on ongoing cytokine signaling, not epigenetic changes, as cytokine removal reverses enhancer formation and memory.

This study compares the training effects of different Dectin-1 ligands on human monocytes and finds that zymosan induces a distinct phenotype compared to β-glucan through differential activation of signaling pathways.

The paper shows that high-dose IFN-β activates both ISGF3 and GAF in epithelial cells, with GAF enhancing ISGF3 target gene expression through co-localization and chromosome looping.

This study shows that NFκB activity dynamics determine stimulus-specific epigenomic reprogramming in macrophages by promoting de novo enhancer formation.