Author

Waghela Deeksha

Indian Institute of Technology HyderabadORCID 0000-0002-0190-7777Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Basant Kumar PateliD· 2 shared Akarsh BajpaiiD· 1 shared Amandeep GirdhariD· 1 shared Anamika BhargavaiD· 1 shared Eerappa RajakumaraiD· 1 shared Ganesan PrabusankariD· 1 shared Gembali Raju· 1 shared Himanshu JoshiiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Basant Kumar PatelORCID

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2 papers

Recent·Most cited

BiochemistryChemical Biology & Drug DesignPeer-reviewedOct 1, 2024

In silico and in vitro studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in TDP-43 proteinopathies.

Vini D. Meshram, Ramkumar Balaji, Preethi Saravanan…·Basant Kumar Patel

This paper shows EGCG inhibits TDP-43 aggregation and cytotoxicity in vitro through binding to its C-terminal domain.

8 citations

humanprotein structure

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BioinformaticsInternational Journal of Biological MacromoleculesPeer-reviewedJan 7, 2020

Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid-liquid phase separation (LLPS) of TDP-432C-A315T by AIM4.

Amandeep Girdhar, Vidhya Bharathi, Vikas Ramyagya Tiwari…·Basant Kumar Patel

This study uses computational methods to identify AIM4's binding site on TDP-43 and shows it inhibits LLPS of a TDP-43 mutant in vitro.

56 citations

protein structurestatistical model

𝕏 PostBluesky