Author

Basant Kumar Patel

Indian Institute of Technology HyderabadORCID 0000-0001-9465-4803Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Bioinformatics· 2 Biophysics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:protein structure· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Himanshu JoshiiD· 3 shared Ramkumar BalajiiD· 3 shared Vidhya BharathiiD· 3 shared Amandeep GirdhariD· 2 shared Preethi SaravananiD· 2 shared Waghela DeekshaiD· 2 shared Akarsh BajpaiiD· 1 shared Anamika BhargavaiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiophysics

Himanshu JoshiORCID

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Author profile →

6 papers

Recent·Most cited

BiophysicsbioRxivPreprintJun 17, 2026

Mechanistic Insights into Unfolding of the Mitochondrial Localization Sequence M1 of TDP-43 and Identification of a MAPKAPK2 Inhibitor as a potential binder of M1 for inhibition of TDP-43's Aberrant Mitochondrial Localization

Ramkumar Balaji, Shanu Bhardwaj, Jessica Baa…·Basant Kumar Patel

This study investigates the unfolding mechanism of TDP-43's mitochondrial localization sequence M1 and identifies a potential inhibitor, ZINC73240059, that binds M1 to block TDP-43's aberrant mitochondrial localization in ALS.

DOI 10.64898/2026.06.17.732848

humanproteomics

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BioinformaticsbioRxivPreprintNov 13, 2025

Elucidating the conformational dynamics of the mitochondrial localization signal, M3, of TDP-43 and accessing potential inhibitors using molecular docking and simulation

Ramkumar Balaji, Himanshu Joshi, Basant Kumar Patel

This study identifies vitamin D3 as a potential inhibitor of TDP-43's mitochondrial mis-localization through molecular docking and simulation of the M3 region.

DOI 10.1101/2025.11.13.688389

humanprotein structure

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BiochemistryNew Journal of ChemistryPeer-reviewedJan 1, 2025

Enhanced in vitro aggregation, but not phase separation, of TDP-43 and its C-terminal fragments generate deep-blue autofluorescence.

Preethi Saravanan, Vidhya Bharathi, Priyadarshini Veerabhadraswamy, Basant Kumar Patel

This study shows that enhanced in vitro aggregation of TDP-43 and its fragments generates deep-blue autofluorescence, which is not emitted by phase-separated structures or oligomers.

2 citations

proteomicsexperimental assay

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BiochemistryChemical Biology & Drug DesignPeer-reviewedOct 1, 2024

In silico and in vitro studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in TDP-43 proteinopathies.

Vini D. Meshram, Ramkumar Balaji, Preethi Saravanan…·Basant Kumar Patel

This paper shows EGCG inhibits TDP-43 aggregation and cytotoxicity in vitro through binding to its C-terminal domain.

8 citations

humanprotein structure

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GeneticsBiochimica et Biophysica Acta (BBA) - Molecular Cell ResearchPeer-reviewedFeb 27, 2021

Role of CNC1 gene in TDP-43 aggregation-induced oxidative stress-mediated cell death in S. cerevisiae model of ALS.

Vidhya Bharathi, Amandeep Girdhar, Basant Kumar Patel

The paper investigates the role of CNC1 gene in TDP-43 aggregation-induced oxidative stress-mediated cell death in a yeast model of ALS, finding that CNC1 deletion reduces TDP-43 toxicity.

24 citations

yeastexperimental assay

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BioinformaticsInternational Journal of Biological MacromoleculesPeer-reviewedJan 7, 2020

Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid-liquid phase separation (LLPS) of TDP-432C-A315T by AIM4.

Amandeep Girdhar, Vidhya Bharathi, Vikas Ramyagya Tiwari…·Basant Kumar Patel

This study uses computational methods to identify AIM4's binding site on TDP-43 and shows it inhibits LLPS of a TDP-43 mutant in vitro.

56 citations

protein structurestatistical model

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