Author

Xiaohong Zhou

University of PittsburghORCID 0000-0002-0219-8386Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:structural biology· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Organism:virus· 1

Frequent Co-Authors

Guillermo A. CaleroiD· 2 shared Sandra Viviana VergaraiD· 2 shared Ulises SantiagoiD· 2 shared Aina E. CoheniD· 1 shared Alexander DeitersiD· 1 shared Brisa Caroline Alves ChagasiD· 1 shared Daniel Calero· 1 shared Dennis P. StegmanniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Guillermo A. CaleroORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 21, 2025

Time-Resolved Crystallography Reveals the Mechanisms of GTP hydrolysis for N-RAS and the Oncogenic Mutants G12C, G12V and Q61L

Guowu Lin, Paola Zinser Peniche, Xiaohong Zhou…·Guillermo A. Calero

This study uses time-resolved crystallography to capture GTP hydrolysis intermediates of N-RAS and oncogenic mutants, revealing shared and distinct reaction mechanisms.

3 citations

humanstructural biology

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BiophysicsNature CommunicationsPeer-reviewedDec 4, 2024

Structures of kinetic intermediate states of HIV-1 reverse transcriptase DNA synthesis

Sandra Viviana Vergara, Xiaohong Zhou, Ulises Santiago…·Guillermo A. Calero

This study captures 11 structures of HIV-1 reverse transcriptase during DNA synthesis, revealing intermediate states and mechanisms of dATP incorporation and drug resistance.

13 citations

virusstructural biology

𝕏 PostBluesky