Author

Dennis P. Stegmann

Paul Scherrer InstituteORCID 0000-0003-4391-0891Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:structural biology· 2 Research Focus:benchmarking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Aina E. CoheniD· 1 shared Alexander DeitersiD· 1 shared Andrea Flores-IbarraiD· 1 shared B. F. PedriniiD· 1 shared Bence OlasziD· 1 shared Brisa Caroline Alves ChagasiD· 1 shared Celestino PadesteiD· 1 shared Daniel Calero· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Aina E. CohenORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 21, 2025

Time-Resolved Crystallography Reveals the Mechanisms of GTP hydrolysis for N-RAS and the Oncogenic Mutants G12C, G12V and Q61L

Guowu Lin, Paola Zinser Peniche, Xiaohong Zhou…·Guillermo A. Calero

This study uses time-resolved crystallography to capture GTP hydrolysis intermediates of N-RAS and oncogenic mutants, revealing shared and distinct reaction mechanisms.

3 citations

humanstructural biology

𝕏 PostBluesky

BiophysicsIUCrJPeer-reviewedJul 3, 2024

Fixed-target time-resolved crystallography at XFELs: the scourge of light contamination but reduced sample consumption

Guillaume Gotthard, Andrea Flores-Ibarra, Melissa Carrillo…·Przemysław Nogły

The paper validates a fixed-target delivery system for XFEL crystallography, showing reduced sample consumption and light contamination control for light-sensitive proteins.

13 citations

cryo-EMstructural biology

𝕏 PostBluesky