Gisela Cairo

The paper develops a mathematical model to show that Rim4 degradation and Ama1 translation are essential for irreversible meiotic exit in budding yeast.

The paper shows that in Mos-deficient eggs, polar bodies can re-enter the cell cycle and divide, leading to tumor formation due to disrupted MOS/MAPK signaling.

The paper identifies Clb4 as a factor preventing premature sister centromere separation in meiosis I of budding yeast, with effects dependent on genetic background.

This study shows that MOS signaling is essential for meiotic cell cycle regulation and maintaining the egg transcriptome required for developmental competence.