ImmunologybioRxivPreprint
Essential role of an acidic endosomal environment in JAK3-mediated signal transduction
Yuji Amano, Nobuyuki Tanaka, Toshikazu Takeshita, Katsuhiko Kojima
This study shows that acidic endosomal environments are essential for JAK3-mediated signal transduction and that IAVNs like chloroquine and monensin disrupt this process, affecting cytokine signaling and arthritis.
DOI 10.1101/2023.09.07.556780