Michael J. Ragusa

This study identifies the mechanism by which Atg11 recruits Atg9 in yeast selective autophagy through structural and biochemical analysis.

This study determines the crystal structure of Atg23 and identifies hydrophobic interactions between Atg23 and both N- and C-terminal regions of Atg9.

This study shows that membrane composition regulates self-organized cortical patterning of active Rho and F-actin in an artificial cell cortex.

This study shows Atg11 binds autophagosomal-like membranes via an amphipathic helix, clustering vesicles on cargo mimetics to initiate mitophagy.

This study identifies overlapping SLiMs in NBR1 that mediate interactions with multiple autophagy receptors, revealing cooperative binding mechanisms and the regulatory role of phosphorylation.

This study identifies the molecular mechanisms by which CifR, an epoxide-sensing transcriptional repressor, regulates the virulence gene cif in Pseudomonas aeruginosa.

The paper describes engineered NEMO constructs that enable structural analysis of the NEMO/IKK interaction, revealing a novel ligand binding motif and informing inhibitor design.