Takayuki Uchihashi

The paper uses machine learning to discover antimicrobial peptides through an unintended functional property revealed by the algorithm.

This paper identifies a metastable dimeric intermediate essential for forming native-like spidroin fibrils, but shows dehydration causes irreversible transition to amyloid-like cross-β structures.

This paper introduces high-speed atomic force-Raman microscopy (HS-AFRM) to combine structural and chemical analysis, enhancing the understanding of biomolecular dynamics.

The paper uses high-speed AFM and biophysical methods to study dynamic conformational changes in multidomain glycosyltransferases, revealing diverse organizational strategies.

This study identifies a conserved residue in FlhA that couples export gate activation to substrate specificity switching in bacterial flagellar assembly.

This study generates and characterizes monoclonal IgM and IgG antibodies against norovirus variants GII.4 and GII.17, revealing differences in binding mechanisms and affinity.

This study shows that ether phospholipids modulate mechanosensory and thermosensory responses in Drosophila by affecting PIEZO and TRPA1 channels.

This study investigates the role of Pro230 in the hinge region of IgG by deleting it, revealing structural changes and functional effects on FcγRI-mediated activity.

This study combines optical tweezers with high-speed AFM to visualize DNA folding dynamics, revealing reversible structural changes and metastable intermediates.

This study identifies a dual-domain chitinase in marine bacteria that enhances chitin binding and retention, improving resource acquisition in the ocean.

This study shows that myosin V can perform ATP-free walking by converting strain energy from actin binding into mechanical work, similar to ATP-dependent walking.

This study reports the cryo-EM structure of the ZapA-FtsZ complex, revealing how ZapA interacts with FtsZ to regulate bacterial cell division.

This paper uses high-speed in-line force mapping to study dynamic mechanical properties of living E. coli during division, revealing transient phenomena like localized stiffening and membrane pore formation.

The paper reports the near-atomic structure of the S-ring from Vibrio alginolyticus flagellar motor using cryo-EM, revealing structural differences compared to Salmonella.

This paper uses DNA origami nanoblocks to visualize DE-cadherin ectodomain interactions and reveal a hinge-like structure involved in mechanical flexibility and adhesion-like processes.

This study identifies the role of FlhA's GYXLI motif and the flagellar ATPase complex in regulating substrate specificity switching of the fT3SS during flagellar assembly in Salmonella.

The paper presents the cryo-EM structure of human ATAD2 in the ATP state and its complex with histone H3H4, revealing structural organization and a regulatory mechanism involving inter-subunit communication.

This study uses high-speed AFM to visualize pH-induced AB42 peptide nucleation and identifies key molecular stages in oligomer formation.