Maya English

This study identifies cGAS-STING pathway activation as a key mechanism of inflammation in VEXAS, showing that UBA1 mutations disrupt ERAD and mitochondrial homeostasis, leading to STING-driven inflammation.

This study identifies shared and distinct mechanisms of UBA1 inactivation in VEXAS syndrome and related diseases, revealing how different mutations affect ubiquitin transfer to E2 enzymes.