Sunny J. Jones

The paper uses CRISPRi and single-cell RNA-seq to reverse engineer gene regulatory networks in colorectal cancer cells, revealing autoregulatory and cooperative mechanisms.

The paper identifies 407 Master-Regulator proteins that canalize cancer genomics into transcriptional subtypes and links genetic alterations to tumor biology through modular regulatory architectures.

The paper introduces an algorithm to reconstruct context-specific molecular interaction maps centered on oncoproteins, validating it with KRAS in lung adenocarcinoma and identifying novel synthetic lethal proteins.