Erin M. Coyne

The paper presents a pan-cancer ex vivo drug screen atlas with 2.1M experiments, identifying tissue-specific drug sensitivities and demonstrating their predictive value for clinical profiles.

The paper investigates how cancer-associated fibroblasts (CAF) influence tumor cell behavior in pancreatic ductal adenocarcinoma by driving EMT and altering cell subtypes, with IL-8 playing a key modulatory role.

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

The paper uses spatial analysis to show metastasis-initiating cancer cells in breast tumors are closely associated with specific macrophage subtypes, suggesting these interactions promote metastasis.

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.