Author

Tommy Alain

University of OttawaORCID 0000-0002-0396-9138Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Tommy Alain1 paper

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Christos G. GkogkasiD· 2 shared Seyed Mehdi JafarnejadiD· 2 shared Aitor GarziaiD· 1 shared Alejandro Schcolnik‐CabreraiD· 1 shared Anavasadat Sadr Hashemi NejadiD· 1 shared Angela P. Hackett· 1 shared April A. N. RoseiD· 1 shared Caroline CapdevielleiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Christos G. GkogkasORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 8, 2026

eIF4A inhibition disrupts resistance-associated translational and metabolic programs in BRAF-mutant melanoma

Alejandro Schcolnik‐Cabrera, Meriem Takdenti, Anavasadat Sadr Hashemi Nejad…·Laura Hulea

This study shows eIF4A inhibition disrupts resistance mechanisms in BRAF-mutant melanoma by targeting translational and metabolic programs, improving tumor control when combined with BRAF inhibitors.

DOI 10.64898/2026.09.03.749206

humanbulk RNA-seq

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Cell BiologyNucleic Acids ResearchPeer-reviewedSep 17, 2024

Ribosome Quality Control Mechanism Mitigates the Cytotoxic Impacts of Ribosome Collisions Induced by 5-Fluorouracil

Susanta Chatterjee, Parisa Naeli, Okan Onar…·Seyed Mehdi Jafarnejad

This study shows that 5-Fluorouracil induces ribosome collisions, which are mitigated by the RQC mechanism through mTOR-dependent regulation of RQC factors.

18 citations

humanmetabolomics

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Molecular BiologyCell ReportsPeer-reviewedDec 1, 2019

Induction of an alternative 5’ leader enhances translation of Inpp5e and resistance to oncolytic virus infection

Huy‐Dung Hoang, Tyson Ernst Graber, Jianjun Jia…·Tommy Alain

The paper identifies an alternative 5' leader in Inpp5e mRNA that enhances translation and confers resistance to oncolytic virus infection in cancer cells.

18 citations

mousebulk RNA-seq

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