Christos G. Gkogkas

This study identifies ZC3H7A and ZC3H7B as RNA-binding proteins that regulate mRNA stability and translation by targeting non-optimal A/U3 codons.

This study shows that translational control in spinal cord neurons, particularly in inhibitory and PV+ interneurons, significantly influences gene expression and pain hypersensitivity during the chronic phase of neuropathic pain.

This study shows that SNCA triplication in human midbrain organoids causes early proteostasis disruption and extracellular matrix changes before neurodegeneration.

This study uses cerebral organoids to show that CNTNAP2 loss causes imbalanced GABA/glutamate neuron differentiation and increased AKT/mTOR signaling, linked to ASD pathophysiology.

This study shows that 5-Fluorouracil induces ribosome collisions, which are mitigated by the RQC mechanism through mTOR-dependent regulation of RQC factors.

The paper identifies mRNA sequences that stall ribosomes in neurons, linking these sequences to FMRP association and stalled polysome function.

This study shows that eIF4E phosphorylation is essential for maintaining dentate gyrus LTP in vivo by recruiting β-catenin to the mRNA cap and enhancing Wnt pathway translation.

The paper identifies an alternative 5' leader in Inpp5e mRNA that enhances translation and confers resistance to oncolytic virus infection in cancer cells.