Author
Harvard UniversityORCID 0000-0002-0434-7787Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Avinash Sharma, Khairun Nisaa, Lina Blanco-Rodriguez…·Carlos Giovanni Silva-Garcia
This study shows increasing PCAF-1 in C. elegans extends lifespan, preserves healthspan, and enhances stress responses by reprogramming transcription and improving proteostasis.
Purbasha Dasgupta, Ryan J Lee, Erica Dinneen, Carlos Giovanni Silva-García
The paper develops GG-Clock, an image-based aging clock using germ granule remodeling in C. elegans, showing it predicts age and responds to fasting.
Erica Dinneen, Purbasha Dasgupta, Avinash Sharma…·Carlos G. Silva-García
The paper introduces a universal single-copy knock-in system for C. elegans that allows transgene insertion at specific loci using CRISPR/Cas9.
Carlos G. Silva-García, Laura Ivón Láscarez-Lagunas, Katharina Papsdorf…·William B. Mair
This study identifies CRTC-1's role in balancing histone trimethylation and acetylation to promote longevity in C. elegans.
Carlos G. Silva-García, William B. Mair
The paper confirms that set-2 mutants in C. elegans extend lifespan when fed HT115 E. coli, but not OP50-1, suggesting diet-dependent regulation of COMPASS complex effects on aging.
Yue Zhang, Anne Lanjuin, Suvagata Roy Chowdhury…·William B. Mair
Carlos G. Silva-García, Caroline Heintz, Sneha Dutta…·William B. Mair
The paper introduces a CRISPR/Cas9-based system for inserting single-copy transgenes in C. elegans with tissue-specific regulation.