Aomeng Cui

This study shows that SOX7 and ERG reprogram human pluripotent stem cell-derived cells into brain endothelial cells with forebrain regional bias, improving BBB modeling.

This study identifies endothelial type I interferon signaling as a regulator of vascular normalization after ischemic brain injury, showing it reduces BBB disruption and promotes junctional stability.

This paper generates and characterizes reprogrammed brain microvascular endothelial cells from hiPSCs using transcription factors FOXF2 and ZIC3, showing improved BBB properties and integration with neural cells in a 3D system.