Uğur Akcan

This study shows that SOX7 and ERG reprogram human pluripotent stem cell-derived cells into brain endothelial cells with forebrain regional bias, improving BBB modeling.

This study identifies a high prevalence of CNS-directed autoantibodies in schizophrenia patients, linking them to disease severity, treatment resistance, and potential therapeutic targets.

This study identifies IL-17A-IL-17RA signaling in microglia as a critical driver of BBB dysfunction after GAS infections using single-cell RNA sequencing and spatial transcriptomics.

This paper generates and characterizes reprogrammed brain microvascular endothelial cells from hiPSCs using transcription factors FOXF2 and ZIC3, showing improved BBB properties and integration with neural cells in a 3D system.

The paper develops multimeric sACE2 decoys using SunTag or MoonTag systems, showing >100-fold increased SARS-CoV-2 neutralization compared to monomeric sACE2.