Kohei Fujikura

This study shows that 3D assessments are necessary to accurately determine tissue composition and neoplastic content, as 2D methods under-sample spatial heterogeneity.

This study identifies a high burden of non-coding mutations and mitochondrial heteroplasmy in type B1 and B2 thymomas, suggesting these may drive tumorigenesis despite low coding mutations.

This paper introduces SpaceMarkers, a method to infer molecular changes from cell-cell interactions in spatial transcriptomics data, applied to tumor-immune interactions in metastasis and immunotherapy.