Bhoomika Basu Mallik

Reward-guided inference-time search over the Proteína-Complexa sequence-structure codesign model yields validated binders across 127 targets, kinases and a free carbohydrate, with codesigned sequences outperforming ProteinMPNN redesign.

This paper introduces an AI-based framework for designing responsive protein oligomers that assemble in response to chemical or phosphorylation triggers, validated through experimental testing.

This study shows that structural flexibility in computationally designed protein assemblies leads to multiple architectures, expanding their functional possibilities.