Author
Burnet InstituteORCID 0000-0002-0618-4731Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Claudia BG Barnes, Mrittika Chowdury, Dawson B. Ling…·Paul R. Gilson
This paper identifies MMV006833 as an inhibitor of PfSTART1 in P. falciparum but shows it is ineffective against P. berghei due to structural differences and other factors.
Martina Soledad Paoletta, Thorey K. Jonsdottir, Alison C. Kemp…·Ellen Bushell
This study identifies two Plasmodium virulence factors involved in lipid metabolism and disease progression by analyzing their function in vivo.
Thorey K. Jonsdottir, Martina Soledad Paoletta, Takahiro Ishizaki…·Ellen Bushell
The paper develops a scalable CRISPR-Cas9 system for Plasmodium berghei to enable genome-wide knockout screens.
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson…·Paul R. Gilson
The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.
Sophia Raine C. Hernandez, Ravish Rashpa, Thorey K. Jonsdottir…·Ellen Bushell
The paper identifies EMAP3 as a new parasite protein exposed on the surface of P. berghei infected red blood cells, which interacts with EMAP1 but is not the main CD36-binding protein.
Madeline G. Dans, Henni Piirainen, William Nguyen…·Paul R. Gilson
This study identifies MMV020291 as a compound that targets actin-1/profilin dynamics in Plasmodium falciparum, inhibiting red blood cell invasion and apicoplast segregation.