Effect of ORL-1 on Cav1.2 calcium channels
Aiden J Shaver, Ivana Assis Souza, Laurent Ferron…·Gerald Werner Zamponi
This study shows ORL-1 interacts with Cav1.2, reducing its membrane expression without changing its biophysical properties.
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University of CalgaryORCID 0000-0002-0644-9066Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Aiden J Shaver, Ivana Assis Souza, Laurent Ferron…·Gerald Werner Zamponi
This study shows ORL-1 interacts with Cav1.2, reducing its membrane expression without changing its biophysical properties.
Aynal Hoque, Vishal Tanaji Khade, EDE Venkata Gopal…·Giriraj Sahu
This study identifies asymmetric π-H and π-π quadrangle interactions at the DI-DII interface of L-type channels as the molecular basis for voltage-dependent facilitation.
Wilten Nicola, Ali Mahani, Raymond W. Turner, Gerald Werner Zamponi
The paper demonstrates subthreshold asynchronous computations in biophysically detailed neuron networks using graded synaptic transmission without spiking.
Devon Khousakoun, Ivana Assis Souza, Laurent Ferron…·Gerald Werner Zamponi
This study examines the biophysical effects of a Cav2.3 channel mutation (L228P) linked to DEEs using whole-cell patch-clamp, finding a shift in voltage-dependent activation and inactivation towards hyperpolarized potentials.