Takeshi Noda

This study determines the structure of BoDV-1 nucleoprotein-RNA complexes using cryo-EM, revealing RNA-independent assembly mechanisms and conserved features across the Bornaviridae family.

This study presents the cryo-EM structure of the PINK1-HSP90-CDC37 complex, revealing how HSP90-CDC37 stabilizes PINK1 and how mutations may disrupt this process.

The paper identifies key nucleocapsid proteins in Marburg and Ebola viruses and shows their role in nucleocapsid assembly and transport, highlighting a conserved motif as a potential antiviral target.

This paper shows that influenza A virus sequesters dsRNA in infected cells to evade the innate immune response, with NS1 masking dsRNA and NEP controlling its nuclear translocation.

The paper develops isogenic lung-on-chip models from iPSC-derived cells to study tissue-specific immune responses to SARS-CoV-2 and Influenza viruses.

This study determines the structure of the Ebola virus nucleocapsid using cryo-EM and identifies VP24's role in assembly and function.

This study identifies COPI as essential for SARS-CoV-2 virion transport from the ERGIC, showing that COPB2 depletion inhibits viral replication.

The paper determines the structures of intermediate stages of pore formation by the Iota toxin's membrane-binding component using cryo-EM, revealing a stepwise maturation mechanism.

The paper identifies a splicing modifier that switches OAS1 isoforms, enhancing resistance to SARS-CoV-2 infection in human lung cells.

The paper develops a live-cell imaging system to visualize Marburg virus nucleocapsid-like structures outside BSL-4 labs, showing they transport similarly to actual nucleocapsids.