Memory-safe high-performance sequence mapping with rammap
The paper introduces rammap, a Rust reimplementation of minimap2 with improved performance and memory safety, demonstrating compatibility and efficiency improvements.
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University of North Carolina at Chapel HillORCID 0000-0002-0673-9418Unclaimed ORCID profile · follow to get notified of new preprints
12 papers
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The paper introduces rammap, a Rust reimplementation of minimap2 with improved performance and memory safety, demonstrating compatibility and efficiency improvements.
Sara K. Peterson, A McCauley Massie, Alex Rubinsteyn…·Ian J. Davis
The paper introduces vmwhere, a tool for analyzing tetrameric microsatellites from long-read sequencing data, and shows its application in linking GGAA repeat structure to chromatin state in Ewing sarcoma.
Jeffrey Lee Jensen, Sara K. Peterson, Maria J. Sambade…·B. V. Vincent
This study identifies PRAME as a therapeutic target in NUT carcinoma, showing its high expression and susceptibility to T-cell mediated cytotoxicity via PRAME epitopes presented by HLA Class I molecules.
Yue Wang, Oliver Cope, Jingting Chen…·Elizabeth Brunk
The paper shows that ecDNA allows tumors to adapt rapidly by maintaining a spectrum of gene expression levels across cells, rather than relying on clonal expansion.
Adam M. M. Stuckert, David A. Turissini, Emmanuel R. R. D’Agostino…·Daniel Ricardo Matute
The paper investigates genetic diversity and sex differentiation in Lutzomyia longipalpis, identifying sex chromosomes and population structure across South America.
Julie K. Geyer, Kofi Boakye Opoku, John Lin…·Jeremy Wang
This study demonstrates real-time genomic classification of pediatric acute leukemia using long-read sequencing with adaptive sampling, identifying key alterations faster than traditional methods.
Vincent Boudreau, Ashley R. Albright, Ben T. Larson…·Wallace F. Marshall
This paper describes the cell biology and genome of Stentor pyriformis, a mixotrophic ciliate, revealing unique features of its endosymbiotic relationship with Chlorella variabilis.
Q X Charles Mak, Ryan R. Wick, James Holt, Jeremy Wang
The paper introduces FMLRC2, a tool for polishing de novo nanopore assemblies, and demonstrates its effectiveness for bacterial and eukaryotic genomes.
Wenbin Zhou, Carolina E. Armijos, Chaehee Lee…·Corbin D. Jones
The paper introduces ptGAUL, a pipeline for assembling plastomes from long-read data, showing it produces accurate assemblies and revealing long repeats and rearrangements in Juncus plastomes.
Jeremy Wang, Rachel M. Bleich, Sandra Zarmer…·Janelle C. Arthur
The paper develops a long-read sequencing method to identify and distinguish AIEC strains in intestinal tissue, showing their ability to colonize IBD-susceptible mice and induce inflammation.
Gerald Tegha, Emily Jane Ciccone, Robert G. Krysiak…·Jeremy Wang
This study uses whole genome sequencing to analyze the prevalence and spread of antimicrobial resistance genes in E. coli isolates from Malawi, showing increased prevalence of ST131 and blaCTX-M-15.
Daniel Sprague, Shafagh A. Waters, Jessime M. Kirk…·J. Mauro Calabrese
The paper shows non-linear sequence similarity between Xist and Rsx repeat domains, suggesting shared functional roles through similar protein-binding motif enrichments.