Thomas Henry

PRESCOTT predicts the functional impact of missense mutations using sequence and structural data, outperforming existing methods in variant classification and disease-specific mutation analysis.

This study functionally characterizes 34 NLRP3 variants associated with CAPS, identifying functional diversity and inhibitor sensitivity, with implications for diagnosis and drug development.

This study compares the pathogenicity of Staphylococcus aureus and Streptococcus pyogenes isolates toward human myoblasts and keratinocytes, finding higher internalization and cytotoxicity by NSTI-SA in myoblasts.